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N1o1 Nitric Oxide Fresh & Bright Bundle
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N1o1 Nitric Oxide Age-Defiance Bright Eyes Collection
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Couples Performance Bundle
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Nitric Oxide Booster Bundle
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N.O. Beetz Nitric Oxide Supplement
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Nitric Oxide Dyno Duo
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Nitric Oxide Age-Defiance Face Cream
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Nitric Oxide Boosting Age-Defiance Eye Cream
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N1o1 Nitric Oxide Age-Defiance Skincare System
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Nitric Oxide Activating Age-Defiance Serum
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N1o1 Nitric Oxide Lozenges
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N.O. Beetz Nitric Oxide Supplement (Buy 3, Get 1 Free )
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N1o1 Nitric Oxide Lozenges Bundle (Buy 3 Get 1 Free)
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- Boosts your mouth’s natural microbiome
- Freshens breath naturally
- Remineralizes and strengthens enamel
- Fluoride-free formula, free of harsh toxins
- Enhances gum health and circulation
Healthier Gums. Brighter Smiles. More Confidence.
That’s why we created Breath of Life Nitric Oxide Boosting Toothpaste — a revolutionary formula designed to support the oral microbiome that boosts nitric oxide levels, improves circulation, and supports gum health, so you can enjoy a healthier smile every day.

“We have known for more than 100 years that poor oral hygiene leads to increased risk of cardiovascular disease. Today we know that the oral microbiome responsible for optimizing nitric oxide production accounts for the oral-systemic link. Stringent antiseptics, fluoride, and poor oral hygiene all disrupt the oral microbiome. Our nitric oxide–focused line of oral care supports the microbiome, improving nitric oxide production — and thereby oral and systemic health.”
—Dr. Nathan S. Bryan, international expert in nitric oxide biochemistry
How Nitric Oxide Impacts Your Oral Health

Freshens Breath Naturally
Inhibits the growth of cavity-causing bacteria while leaving your mouth fresh and clean.

Boosts Blood Flow & Circulation
Helps boost circulation for healthier gums and improved cardiovascular function.

Oral Microbiome Support
Nurtures beneficial bacteria for a balanced, resilient oral microbiome.

Supports Gum Health
Promotes blood flow and helps fight harmful bacteria to support healthy gums.

Reduces Plaque Build-Up
Supports healthy saliva pH to neutralize acids and reduce plaque buildup.

Elevates Mood & Energy
Feel more vibrant and energized with the natural boost nitric oxide provides.
The Oral-Systemic Link, Backed by Science
The first step of nitric oxide production happens in your mouth. Beneficial oral bacteria convert dietary nitrates into nitrite, which your body turns into nitric oxide — the master molecule that relaxes and widens blood vessels. When harsh antiseptics or fluoride wipe out those bacteria, the pathway shuts down, blood pressure can rise, and gum and heart health both suffer.
Breath of Life is engineered to protect that pathway, not destroy it. It cleans and remineralizes like a premium fluoride-free, hydroxyapatite toothpaste — the same approach embraced by the best-selling natural brands — then goes further by actively supporting the microbiome that fuels nitric oxide production.
Susan Shaffer
President & Co-Founder of N1o1 Nitric Oxide
What is nitric oxide?
How does nitric oxide affect oral health?
What makes Breath of Life different from other toothpastes?
How long until I see results?
Is it safe for daily use and sensitive teeth?
MEET THE FOUNDER
Dr. Nathan Bryan: A Leading Authority on Nitric Oxide
Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. With more than 25 years of research in cardiovascular health, his discoveries have shaped the field of nitric oxide therapy and led to product innovations that have improved patient care worldwide.

A Pioneer in Nitric Oxide Science
With over 25 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.

Clinically Backed & Scientifically Proven
His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the N1o1 CardioSmile Nitric Oxide Boosting Toothpaste you’re about to experience.

On a Mission to Improve Lives
Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.
Natural, Powerful Ingredients
Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. With more than 25 years of research in cardiovascular health, his discoveries have shaped the field of nitric oxide therapy and led to product innovations that have improved patient care worldwide.

Hydroxyapatite
Rebuilds and strengthens enamel — a natural, fluoride-free alternative for long-lasting protection.

Potassium Nitrate
Soothes nerve endings to reduce tooth sensitivity.

Zinc Citrate
Helps prevent plaque from hardening into tartar.

Xylitol & Erythritol
A natural ingredient known for its anti-inflammatory and healing properties, often used to reduce swelling, bruising, and pain

Hydrated Silica & Calcium Carbonate
Gently polish teeth to remove surface stains for a brighter smile — without harsh abrasion.

Essential Oil Blend
Peppermint, spearmint, wintergreen, tea tree, and cinnamon for fresh breath and natural antimicrobial benefit.

Full Ingredient List
Glycerin, Water, Sorbitol, Hydrated Silica, Calcium Carbonate, Potassium Nitrate, Xylitol, Hydroxyapatite, Mentha Piperita (Peppermint) Oil, Xanthan Gum, Mentha Spicata (Spearmint) Leaf Oil, Gaultheria Procumbens (Wintergreen) Leaf Oil, Menthol, Cocos Nucifera (Coconut) Oil, Zinc Citrate, Citrus Aurantium Dulcis (Orange) Peel Oil, Citrus Limon (Lemon) Peel Oil, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Cinnamomum Zeylanicum Bark Oil, Eucalyptus Globulus Leaf Oil, Thymus Vulgaris (Thyme) Flower/Leaf Oil, Erythritol, Cellulose Gum, Sodium Lauroyl Sarcosinate.