How To Use
- Using clean hands apply to clean skin AM and PM.
- Dab gently around the eye and massage into the skin.
- Allow to fully absorb 1-2 minutes
NOTE: Avoid getting the product into the eye.
Maximum of 2 per order.
$79.98
In stock
NOTE: Avoid getting the product into the eye.
| Weight | .5 oz |
|---|---|
| Dimensions | 2.5 × 2.5 × 2 in |
“Loss of nitric oxide production is recognized as the earliest event in the onset and progression of most, if not all, chronic diseases, including the number one killer of men and women worldwide—cardiovascular disease.” —Dr. Nathan S. Bryan
Embrace the next generation of skincare with N1o1 Nitric Oxide Boosting Age-Defiance Face Cream, a novel formulation developed by Dr. Nathan S. Bryan, the renowned biochemist. Use this pioneering skincare product after the N1o1 nitric oxide activating serum to rejuvenate skin from the inside out, addressing the root cause of aging skin. The result is a noticeable reduction in the appearance of fine lines and wrinkles, enhanced skin tone, and a youthful glow you’ll love.
Our Age-Defiance Face Cream works deep within your skin at a cellular level to help diminish signs of aging. It combines three remarkable anti-aging ingredients to specifically target problem areas: Nitric Oxide for promoting overall skin health and circulation to the skin; complex peptides for rejuvenating skin, and Epidermal Growth Factor (EGF) to stimulate collagen and elastin production.
Introducing AMAZING INGREDIENTS with the N1o1 Age-Defying Gel Cleanser that joins natural cleansers with natural botanical ingredients. It works wonderfully with N1o1 nitric oxide-activated anti-aging serum, face cream, and eye cream. The BENEFITS are immense:
Statements made have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Experience the luxury of this botanical-infused face cream that reduces the appearance of wrinkles, combined with the science-backed benefits of Nitric Oxide. For optimal results, pair it with our N1o1 Nitric Oxide Activating Anti-Aging Serum to achieve maximum Nitric Oxide production and a comprehensive anti-aging skincare routine. Rediscover the youthful you with N1o1.
Statements made have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Due to popular demand, limit 1 per order!
“Loss of nitric oxide production is recognized as the earliest event in the onset and progression of most, if not all, chronic diseases, including the number one killer of men and women worldwide—cardiovascular disease.” —Dr. Nathan S. Bryan
Clean ingredients
Cruelty-free
Vegan
Gluten-free
Low Sugar
Non-GMO
A lightweight oil rich in antioxidants and essential fatty acids, known for its moisturizing, anti-inflammatory, and skin-repairing properties.
A natural antioxidant with anti-inflammatory and antimicrobial properties, used to protect and rejuvenate the skin.
A natural ingredient known for its anti-inflammatory and healing properties, often used to reduce swelling, bruising, and pain
A nourishing ingredient derived from olive oil, known for its moisturizing, skin-softening, and anti-aging properties.
Water, Cetearyl Alcohol, Glyceryl Stearate SE, Squalane, Ceteareth-20, Glycerin, Sodium Nitrite, Magnesium Aluminum Silicate, Sodium PCA, Sodium Hyaluronate, Butylene Glycol, Polyacrylamide, Palmitoyl Tripeptide-1, Lecithin, Acetyl Glutamine, Palmitoyl Tetrapeptide-7, sh-Oligopeptide-1, sh-Oligopeptide-2, Cetyl Esters, Humulus Lupulus (Hops) Extract, sh-Polypeptide-1, sh-Polypeptide-9, Equisetum Hyemale Extract, sh-Polypeptide-11, Pinus Strobus Cone Extract, Lecithin, Bacillus/Folic Acid Ferment Filtrate Extract, Hydrogenated Ethylhexyl Olivate, , C13-14 Isoparaffin, Phenoxyethanol, Cetyl Alcohol, 1,2-Hexanediol, Caprylyl Glycol, Laureth-7, Polysorbate 20, Carbomer, Titanium Dioxide
MEET THE FOUNDER
Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.
With over 20 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.
His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the N1o1 Nitric Oxide Lozenges you’re about to experience.
Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.
[1] The Utilization of a Topical Nitric Oxide Generating Serum in the Aging Skin Population: A Pilot Study
Annals of Plastic & Reconstructive Surgery
Greg Chernoff* MD, FRCS(C)
Chernoff Plastic Surgery, Indianapolis, Indiana, Santa Rosa, California, US
Download the PDF
[2] The Utilization of a Nitric Oxide Generating Serum in the Treatment of Active Acne and Acne Scarred Patients
International Journal of Pharmaceutica Analytica Acta
Greg Chernoff
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF
[3] The Utilization of a Nitric Oxide Generating Serum for Improving Vascularity in Wound Healing
Science Repository
Greg Chernoff
Ascension St. Vincent Hospital, USA
Download the PDF
[4] The Utilization of a Topical Nitric Oxide Generating Serum in Aesthetic Medicine
Gavin Publishers
Gregory Chernoff BSc, MD, FRCS(C)
Private Practice, Chernoff Cosmetic Surgeons, Ascension St. Vincent Hospital, Indianapolis IN, USA
Download the PDF
[5] A Novel Combination Therapy in Aesthetic and Reconstructive Surgery: Sea Salt Exfoliation, Cavitating Ultrasound, and High Intensity Multiwavelength LED Treatment: (SaltFacial)
Sciforschen Journal of Clinical and Cosmetic Dermatology
Greg Chernoff, BSc, MD, FRCSC*
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF
AS SEEN IN
Elizabeth Manning –
I’m a 33 year old mother from Colorado where the climate is constantly dry. When I say I’ve tried thousands of moisturizers & face creams, I’m being literal. This one is HANDS DOWN the best one I’ve found. It’s rich, absorbs quickly and the amount that you get is crazy. See pic(s) for reference. This will last me a long time because you only need a pea size for your entire face. I’ve already noticed my skin tone evening, lines softening and dark spots fading after only a few weeks. After week one, I started exploring other products from this line which haven’t disappointed either. Highly recommend pairing this with the Breath of Life serum. This line has changed my entire morning and night regime & I’m blown away by how effective it is. I’m not being paid for this, I’m just really, really happy with the results so far.
If you’re waiting for a sign, this is it: Buy it.
Bradley J. –
I’ve used a few moisturizers now and then on my face but generally I’ve used nothing my entire life. However, the wrinkles around my eyes got my attention. After looking at countless products I was intrigued by the ingredients in N1O1 Nitric Oxide Anti Aging Face Cream, particularly Nitric Oxide. I did a lot of reading and listened to a number of YouTube talks, lectures and interviews and finally decided to try this product. I put it on morning and night. I’m about 80% through my first jar and I have to admit it’s having an effect. Wrinkles are diminishing, lines I guess I’d describe as less deep and over all my skin is smoother – it’s noticeable. I’m also applying it to my neck. The skin just seems a little tighter. I plan to get a second jar and would recommend it.
Tina L. –
This is my second jar the first one was anti aging cream for my eye area and I like it so much that it improves my puffiness and age spots so I decided to try the face cream and so happy by this amazing product even though I have only try it for 10 days since I live in Taipei so it took a long journey through airport and post office to arrive to my hand (through relative who travelled to Taiwan often ) and already so impressed by my skin softness and feeling suppleness , try it you will never regret ! look at how much trouble for me to get it , it should be a prove by itself !
AuthorMom –
I just finished using my first jar of this Nitric Oxide face cream and I have ordered another, even though it is a little pricey. This is seriously amazing. I had two small skin tags under my eyes and they are both gone. In addition, the furrow between my eyes seems much better than in the past. I really like the way this feels as well. I’ve only been using it at night, so I can’t even imagine if I used it twice a day as directed!
Antoinette Simmons –
Has amazing action on some long standing dried non-healing skin lesions. Also pale dry, corpse-like complexion looks alive again. Hoping with long-term use I’ll see more uniformity in color and tone. Moisturizes well but a follow up with another moisturizing product enhances it. Scent is somewhat reminiscent of when parched earth is damped by light rainfall, so not your typical fruitiness of common moisturizers.
Monica L. (verified owner) –
As someone with perpetually dry, flaky skin, I was amazed at how deeply hydrating the Age-Defiance Face Cream is. My skin feels incredibly soft and nourished all day, and the texture has improved so much that my makeup applies more smoothly. It’s like my skin drank a glass of water every morning and night—an absolute game-changer!
Grace N. (verified owner) –
I’ve been searching for a face cream that truly addresses fine lines and wrinkles, and the Age-Defiance Face Cream has exceeded my expectations. The texture is so luxurious—it feels like a treat every time I put it on. Within just a few weeks, I noticed my skin tone looked more even, and the fine lines around my eyes and mouth started to soften. It’s given me a glow I haven’t seen in years, and I finally feel confident going makeup-free. This cream is worth every penny!
Natalie (verified owner) –
I’m absolutely in love with the Age-Defiance Face Cream! After just a few weeks of use, my skin tone looks brighter and more even, and I’ve even received compliments on my radiant glow. The cream feels incredibly lightweight—like a second skin—but it still delivers powerful hydration. What I love most is how quickly it absorbs, leaving no residue, so I can layer it under makeup seamlessly. This has become my secret weapon for glowing, healthy-looking skin!
Sharon (verified owner) –
I can’t believe the difference this face cream has made in my skin! The peptides in the formula work wonders—my cheeks feel noticeably firmer, and there’s a subtle lift around my jawline that wasn’t there before. My skin looks and feels so much more youthful and elastic. It’s like my face got its bounce back! I’m thrilled with the results and can’t imagine my routine without it.
Michael Tegan (verified owner) –
I’ll be honest—I never thought I’d be the guy writing about face cream, but here we are. At 41, I started noticing some deeper lines around my eyes and my skin felt rougher, especially after spending years in the sun. My wife suggested I try something besides basic aftershave, so I picked up the Age-Defiance Face Cream.
The texture is perfect for guys—not heavy or greasy, just smooth and absorbs quickly. I use it morning and night, and within about three weeks, the difference was obvious. My skin feels softer and looks smoother, and those crow’s feet that were really bugging me have definitely softened. Even my forehead lines look less pronounced.
What surprised me most was how natural it felt to use. No complicated routine, no weird smell—just a straightforward product that does what it says. My coworkers have even commented that I look more rested lately. If you’re a guy on the fence about trying something like this, don’t overthink it. This cream works, and your skin will thank you for it.
Kathy (verified owner) –
I like the light-weight texture. Made with lots of good ingredients. it goes on smoothly and absorbs well.
michelle sun (verified owner) –
Next to the lozenges, this is my second favorite product from Dr Nathan. I feel like I can really see a difference in my skin when I stop using it