Breath of Life Nitric Oxide Boosting Toothpaste

Healthier Gums. Brighter Smiles. More Confidence.

Your oral health thrives on strong circulation, healthy gums, a balanced microbiome, and optimal performance. But as you age, nitric oxide production declines — leading to weaker gum health, reduced blood flow, and a less vibrant smile. Conventional fluoride toothpastes and antiseptic mouthwashes make it worse by disrupting the very oral bacteria that produce nitric oxide.

That’s why we created Breath of Life Nitric Oxide Boosting Toothpaste — a revolutionary formula designed to support the oral microbiome that boosts nitric oxide levels, improves circulation, and supports gum health, so you can enjoy a healthier smile every day.

“We have known for more than 100 years that poor oral hygiene leads to increased risk of cardiovascular disease. Today we know that the oral microbiome responsible for optimizing nitric oxide production accounts for the oral-systemic link. Stringent antiseptics, fluoride, and poor oral hygiene all disrupt the oral microbiome. Our nitric oxide–focused line of oral care supports the microbiome, improving nitric oxide production — and thereby oral and systemic health.”

—Dr. Nathan S. Bryan, international expert in nitric oxide biochemistry

Oral Health

How Nitric Oxide Impacts Your Oral Health

This fluoride-free toothpaste is crafted to support a healthy oral microbiome while boosting nitric oxide production — enhancing gum circulation and promoting cardiovascular wellness. Its natural remineralizing properties strengthen enamel, control tartar, and reduce sensitivity. The only toothpaste targeting the nitric oxide microbiome.

Benefits

How To Use

Brush thoroughly at least twice a day, or as directed by your healthcare provider. Apply the desired amount to your toothbrush. For maximum benefit, use daily as consistency yields best results.

Timeline of Benefits

Immediate Use
Enjoy a clean, refreshing brushing experience with a smooth feel and naturally fresh breath.

Within a Few Days
Supports a healthier oral microbiome and balanced saliva pH while helping maintain fresh breath and gum comfort.

Within 2–4 Weeks
Many users notice healthier-looking gums, reduced sensitivity, and a brighter, cleaner smile with consistent daily use.

Long-Term Daily Use
Consistency yields the best results. Over time, daily use helps support long-term oral health, healthy circulation, enamel strength, and overall wellness through nitric oxide support.

Safe for Everyday Use
Formulated with clean, fluoride-free ingredients and designed to be gentle enough for daily use as part of your long-term wellness routine.

* Results can vary from person to person, but many people notice a cleaner, fresher feeling right away, with ongoing benefits becoming more noticeable over time through consistent daily use. Formulated to be safe and gentle for everyday use, this routine works best when used consistently, because long-term wellness and visible results are built through daily habits, not overnight changes.

Watch & Learn

Watch and learn as Susan Shaffer shares how Breath of Life supports the oral microbiome, promotes nitric oxide production, and helps elevate oral and whole-body wellness with a fluoride-free formula.

Susan Shaffer
President & Co-Founder of N1o1 Nitric Oxide

Ingredients

Natural, Powerful Ingredients

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. With more than 30 years of research in cardiovascular health, his discoveries have shaped the field of nitric oxide therapy and led to product innovations that have improved patient care worldwide.

Full Ingredient List

Glycerin, Water, Sorbitol, Hydrated Silica, Calcium Carbonate, Potassium Nitrate, Xylitol, Hydroxyapatite, Mentha Piperita (Peppermint) Oil, Xanthan Gum, Mentha Spicata (Spearmint) Leaf Oil, Gaultheria Procumbens (Wintergreen) Leaf Oil, Menthol, Cocos Nucifera (Coconut) Oil, Zinc Citrate, Citrus Aurantium Dulcis (Orange) Peel Oil, Citrus Limon (Lemon) Peel Oil, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Cinnamomum Zeylanicum Bark Oil, Eucalyptus Globulus Leaf Oil, Thymus Vulgaris (Thyme) Flower/Leaf Oil, Erythritol, Cellulose Gum, Sodium Lauroyl Sarcosinate.

FAQs

What is nitric oxide?

Nitric oxide (NO) is a molecule that helps relax and widen blood vessels — improving circulation, oxygen delivery, and cardiovascular health. It also supports energy, endurance, cognitive function, oral health, and sexual function.

How does nitric oxide affect oral health?

It improves blood flow to the gums and supports your body’s natural defenses against harmful bacteria. It also aids saliva production, which keeps the mouth clean and neutralizes enamel-eroding acids. Without enough nitric oxide, these functions can become compromised, leading to oral-health problems.

What makes Breath of Life different from other toothpastes?

It’s the world’s first toothpaste built around nitric oxide production and a healthy oral microbiome — remineralizing with hydroxyapatite instead of fluoride, nurturing beneficial bacteria rather than wiping them out, relieving sensitivity with potassium nitrate, and freshening with clean essential oils. Developed by leading nitric oxide researcher Dr. Nathan S. Bryan.

How long until I see results?

Many people report an immediately clean, fresh-feeling mouth. Within a couple of days, the oral microbiome and salivary pH improve, and many report more energy and better circulation. Consistent use over a few weeks delivers the best long-term benefits.

Is it safe for daily use and sensitive teeth?

Yes. It’s formulated for daily use with clean, non-toxic ingredients, and potassium nitrate plus hydroxyapatite make it comfortable for sensitive teeth. Suitable for the whole family.

About Dr. Bryan

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Research

[1] Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure
PubMed
Nathan S Bryan, Gena Tribble, Nikola Angelov
Department of Molecular and Human Genetics, Baylor College of Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Periodontics, The University of Texas Health Science Center at Houston, 7000 Fannin, Houston, TX, 77030, USA.
Read The Study

[2] The oral microbiome, nitric oxide and exercise performance
PubMed
Nathan S Bryan, Mia C Burleigh, Chris Easton
Nitric Oxide Innovations, LLC, Houston, TX, USA.
Institute for Clinical Exercise and Health Science, University of the West of Scotland, Blantyre, UK.
Download the PDF

[3] Nathan S. Bryan, PhD, points out how using antiseptic mouthwash can reduce good oral bacteria and cause high blood pressure and other conditions.
Dental Sleep Practice
Nathan S Bryan
Read the Study

[4] Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
PubMed
Nathan S Bryan, John W Calvert, John W Elrod, Susheel Gundewar, Sang Yong Ji, David J Lefer
Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.
Download the PDF

[5] Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults
PubMed
Allison E DeVan, Lawrence C Johnson, Forrest A Brooks, Trent D Evans, Jamie N Justice, Charmion Cruickshank-Quinn, Nichole Reisdorph, Nathan S Bryan, Matthew B McQueen, Jessica R Santos-Parker, Michel B Chonchol, Candace J Bassett, Amy L Sindler, Tony Giordano, Douglas R Seals

Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado
Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado
Integrated Department of Immunology, National Jewish Health, Denver, Colorado
Baylor College of Medicine, Houston, Texas
Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado
TheraVasc, Cleveland, Ohio

Download the PDF

[6] Oral nitrite therapy improves vascular function in diabetic mice
PubMed
Amy L Sindler, Kimberly Cox-York, Lauren Reese, Nathan S Bryan, Douglas R Seals, Christopher L Gentile

Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA

Download the PDF

[7] New Study by Nathan Bryan, PhD., Explains Why the Early Formation of Nitric Oxide in the Mouth by Oral Bacteria Is Essential to Health, Including the Management of Blood Pressure
Newswise
Nathan S Bryan
Read the Article

[8] Nathan S. Bryan, PhD, points out how using antiseptic mouthwash can reduce good oral bacteria and cause high blood pressure and other conditions.
Dental Sleep Practice
Nathan S Bryan
Read the Article

9 reviews for Breath of Life Nitric Oxide Boosting Toothpaste

Rated 5 out of 5

Courtney P., verified buyer – 06/01/2026

I recently started using this toothpaste and WOW, it tastes amazing! I’d used another fluoride-free brand for 7 years, but was so excited to switch to one with the extra benefit of boosting my nitric oxide. Give it a try — you’ll love it!
Rated 5 out of 5

Christian P., verified buyer – 06/01/2026

Tastes great and I highly recommend it. I’ve tried several other fluoride-free toothpaste brands and they don’t even come close. Dr. Bryan, hats off to you for this creation.
Rated 5 out of 5

Daniel H., verified buyer – 06/01/2026

Convenient, effective, refreshing AND good for my health! Couldn’t ask for more. Dr. Bryan is a genius — changing the dental industry!
Rated 5 out of 5

Catherine L., verified buyer – 06/01/2026

I love how this supports both my cardiovascular and oral health. What a revolutionary step in science!
Rated 5 out of 5

Michael Redding – 06/01/2026

I’ve used countless fluoride-free toothpastes over the years, but Breath of Life is in a league of its own. My mouth feels cleaner, my breath stays fresher longer, and I love knowing I’m supporting my overall health every time I brush.
Rated 5 out of 5

Jennifer Taylor – 06/01/2026

Switching to Breath of Life was one of the easiest health upgrades I’ve made. It tastes great, leaves my mouth feeling incredibly clean, and fits perfectly into my daily wellness routine.
Rated 5 out of 5

David K. – 06/01/2026

Once I learned how important the oral microbiome is, I started paying much closer attention to my oral care products. Breath of Life gives me confidence that I’m supporting my health from the mouth up.
Rated 5 out of 5

Kayla M. – 06/01/2026

I’ve tried several fluoride-free toothpastes and none compare. The taste, texture, and clean feeling afterward are outstanding. This has become a permanent part of my routine.
Rated 5 out of 5

Kim S. – 06/04/2026

This is the best fluoride free toothpaste I have ever used. I have been looking and never pleased till now. It was confirmed by my dentist that my mouth is healthier than it has ever been!