Breath of Life Nitric Oxide Boosting Toothpaste Bundle (Bundle of 3)

(5 customer reviews)

The world’s #1 rated Nitric Oxide Boosting toothpaste that boosts your body’s own nitric oxide.

Support your oral and systemic health with the world’s first nitric oxide–enhancing toothpaste. Free from fluoride and harsh toxins, Breath of Life supports your mouth’s natural nitric oxide production — nurturing the oral microbiome that links a healthy smile to a healthy heart. Developed by biomedical scientist Dr. Nathan S. Bryan, International Expert in Nitric Oxide Biochemistry.

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Healthier Gums. Brighter Smiles. More Confidence.

Your oral health thrives on strong circulation, healthy gums, a balanced microbiome, and optimal performance. But as you age, nitric oxide production declines — leading to weaker gum health, reduced blood flow, and a less vibrant smile. Conventional fluoride toothpastes and antiseptic mouthwashes make it worse by disrupting the very oral bacteria that produce nitric oxide.

That’s why we created Breath of Life Nitric Oxide Boosting Toothpaste — a revolutionary formula designed to support the oral microbiome that boosts nitric oxide levels, improves circulation, and supports gum health, so you can enjoy a healthier smile every day.


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“We have known for more than 100 years that poor oral hygiene leads to increased risk of cardiovascular disease. Today we know that the oral microbiome responsible for optimizing nitric oxide production accounts for the oral-systemic link. Stringent antiseptics, fluoride, and poor oral hygiene all disrupt the oral microbiome. Our nitric oxide–focused line of oral care supports the microbiome, improving nitric oxide production — and thereby oral and systemic health.”

—Dr. Nathan S. Bryan, international expert in nitric oxide biochemistry

Oral Health

How Nitric Oxide Impacts Your Oral Health

This fluoride-free toothpaste is crafted to support a healthy oral microbiome while boosting nitric oxide production  enhancing gum circulation and promoting cardiovascular wellness. Its natural remineralizing properties strengthen enamel, control tartar, and reduce sensitivity. The only toothpaste targeting the nitric oxide microbiome.
N1O1 nitric oxide oral health and nitric oxide microbiome and nitric oxide production

Freshens Breath Naturally

Inhibits the growth of cavity-causing bacteria while leaving your mouth fresh and clean.

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Boosts Blood Flow & Circulation

Helps boost circulation for healthier gums and improved cardiovascular function.

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Oral Microbiome Support

Nurtures beneficial bacteria for a balanced, resilient oral microbiome.

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Supports Gum Health

Promotes blood flow and helps fight harmful bacteria to support healthy gums.

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Reduces Plaque Build-Up

Supports healthy saliva pH to neutralize acids and reduce plaque buildup.

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Elevates Mood & Energy

Feel more vibrant and energized with the natural boost nitric oxide provides.

Benefits


How To Use

Brush thoroughly at least twice a day, or as directed by your healthcare provider. Apply the desired amount to your toothbrush. For maximum benefit, use daily as consistency yields best results.

Timeline of Benefits

Immediate Use
Enjoy a clean, refreshing brushing experience with a smooth feel and naturally fresh breath.

Within a Few Days

Supports a healthier oral microbiome and balanced saliva pH while helping maintain fresh breath and gum comfort.

Within 2–4 Weeks

Many users notice healthier-looking gums, reduced sensitivity, and a brighter, cleaner smile with consistent daily use.

Long-Term Daily Use

Consistency yields the best results. Over time, daily use helps support long-term oral health, healthy circulation, enamel strength, and overall wellness through nitric oxide support.

Safe for Everyday Use

Formulated with clean, fluoride-free ingredients and designed to be gentle enough for daily use as part of your long-term wellness routine.

* Results can vary from person to person, but many people notice a cleaner, fresher feeling right away, with ongoing benefits becoming more noticeable over time through consistent daily use. Formulated to be safe and gentle for everyday use, this routine works best when used consistently, because long-term wellness and visible results are built through daily habits, not overnight changes.

Watch & Learn

Watch and learn as Susan Shaffer shares how Breath of Life supports the oral microbiome, promotes nitric oxide production, and helps elevate oral and whole-body wellness with a fluoride-free formula.

Susan Shaffer
President & Co-Founder of N1o1 Nitric Oxide

Ingredients

Natural, Powerful Ingredients

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. With more than 30 years of research in cardiovascular health, his discoveries have shaped the field of nitric oxide therapy and led to product innovations that have improved patient care worldwide.

Hydroxyapatite

Rebuilds and strengthens enamel — a natural, fluoride-free alternative for long-lasting protection.

Potassium Nitrate

Soothes nerve endings to reduce tooth sensitivity.

Zinc Citrate

Helps prevent plaque from hardening into tartar.

Xylitol & Erythritol

A natural ingredient known for its anti-inflammatory and healing properties, often used to reduce swelling, bruising, and pain

Hydrated Silica & Calcium Carbonate

Gently polish teeth to remove surface stains for a brighter smile — without harsh abrasion.

Essential Oil Blend

Peppermint, spearmint, wintergreen, tea tree, and cinnamon for fresh breath and natural antimicrobial benefit.

Full Ingredient List

Glycerin, Water, Sorbitol, Hydrated Silica, Calcium Carbonate, Potassium Nitrate, Xylitol, Hydroxyapatite, Mentha Piperita (Peppermint) Oil, Xanthan Gum, Mentha Spicata (Spearmint) Leaf Oil, Gaultheria Procumbens (Wintergreen) Leaf Oil, Menthol, Cocos Nucifera (Coconut) Oil, Zinc Citrate, Citrus Aurantium Dulcis (Orange) Peel Oil, Citrus Limon (Lemon) Peel Oil, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Cinnamomum Zeylanicum Bark Oil, Eucalyptus Globulus Leaf Oil, Thymus Vulgaris (Thyme) Flower/Leaf Oil, Erythritol, Cellulose Gum, Sodium Lauroyl Sarcosinate.

FAQs

What is nitric oxide?
Nitric oxide (NO) is a molecule that helps relax and widen blood vessels — improving circulation, oxygen delivery, and cardiovascular health. It also supports energy, endurance, cognitive function, oral health, and sexual function.
It improves blood flow to the gums and supports your body’s natural defenses against harmful bacteria. It also aids saliva production, which keeps the mouth clean and neutralizes enamel-eroding acids. Without enough nitric oxide, these functions can become compromised, leading to oral-health problems.
It’s the world’s first toothpaste built around nitric oxide production and a healthy oral microbiome — remineralizing with hydroxyapatite instead of fluoride, nurturing beneficial bacteria rather than wiping them out, relieving sensitivity with potassium nitrate, and freshening with clean essential oils. Developed by leading nitric oxide researcher Dr. Nathan S. Bryan.
Many people report an immediately clean, fresh-feeling mouth. Within a couple of days, the oral microbiome and salivary pH improve, and many report more energy and better circulation. Consistent use over a few weeks delivers the best long-term benefits.
Yes. It’s formulated for daily use with clean, non-toxic ingredients, and potassium nitrate plus hydroxyapatite make it comfortable for sensitive teeth. Suitable for the whole family.

About Dr. Bryan

Dr. Nathan Bryan Dr. Nathan Bryan nitric oxide researcher

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. With more than 30 years of research in cardiovascular health, his discoveries have shaped the field of nitric oxide therapy and led to product innovations that have improved patient care worldwide.

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A Pioneer in Nitric Oxide Science

With over 30 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.

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Clinically Backed & Scientifically Proven

His discoveries have shaped the field of Nitric Oxide therapy, bringing first to market cutting-edge solutions like the N1o1 Breath of Life Nitric Oxide Boosting Toothpaste you’re about to experience.

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On a Mission to Improve Lives

Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.

Research

[1] Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure
PubMed
Nathan S Bryan, Gena Tribble, Nikola Angelov
Department of Molecular and Human Genetics, Baylor College of Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Periodontics, The University of Texas Health Science Center at Houston, 7000 Fannin, Houston, TX, 77030, USA.
Read The Study

[2] The oral microbiome, nitric oxide and exercise performance
PubMed
Nathan S Bryan, Mia C Burleigh, Chris Easton
Nitric Oxide Innovations, LLC, Houston, TX, USA.
Institute for Clinical Exercise and Health Science, University of the West of Scotland, Blantyre, UK.
Download the PDF

[3] Nathan S. Bryan, PhD, points out how using antiseptic mouthwash can reduce good oral bacteria and cause high blood pressure and other conditions.
Dental Sleep Practice
Nathan S Bryan
Read the Study

[4] Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
PubMed
Nathan S Bryan, John W Calvert, John W Elrod, Susheel Gundewar, Sang Yong Ji, David J Lefer
Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.
Download the PDF

[5] Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults
PubMed
Allison E DeVan, Lawrence C Johnson, Forrest A Brooks, Trent D Evans, Jamie N Justice, Charmion Cruickshank-Quinn, Nichole Reisdorph, Nathan S Bryan, Matthew B McQueen, Jessica R Santos-Parker, Michel B Chonchol, Candace J Bassett, Amy L Sindler, Tony Giordano, Douglas R Seals

  • Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado
  • Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado
  • Integrated Department of Immunology, National Jewish Health, Denver, Colorado
  • Baylor College of Medicine, Houston, Texas
  • Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado
  • TheraVasc, Cleveland, Ohio

Download the PDF

[6] Oral nitrite therapy improves vascular function in diabetic mice
PubMed
Amy L Sindler, Kimberly Cox-York, Lauren Reese, Nathan S Bryan, Douglas R Seals, Christopher L Gentile

  • Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
  • Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
  • Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA.
  • Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA

Download the PDF

[7] New Study by Nathan Bryan, PhD., Explains Why the Early Formation of Nitric Oxide in the Mouth by Oral Bacteria Is Essential to Health, Including the Management of Blood Pressure
Newswise
Nathan S Bryan
Read the Article

[8] Nathan S. Bryan, PhD, points out how using antiseptic mouthwash can reduce good oral bacteria and cause high blood pressure and other conditions.
Dental Sleep Practice
Nathan S Bryan
Read the Article

5 reviews for Breath of Life Nitric Oxide Boosting Toothpaste Bundle (Bundle of 3)

  1. Courtney P., verified buyer

    I recently started using this toothpaste and WOW, it tastes amazing! I’d used another fluoride-free brand for 7 years, but was so excited to switch to one with the extra benefit of boosting my nitric oxide. Give it a try — you’ll love it!

  2. Christian P., verified buyer

    Tastes great and I highly recommend it. I’ve tried several other fluoride-free toothpaste brands and they don’t even come close. Dr. Bryan, hats off to you for this creation.

  3. Daniel H., verified buyer

    Convenient, effective, refreshing AND good for my health! Couldn’t ask for more. Dr. Bryan is a genius — changing the dental industry!

  4. Catherine L., verified buyer

    I love how this supports both my cardiovascular and oral health. What a revolutionary step in science!

  5. Michael Redding

    I’ve used countless fluoride-free toothpastes over the years, but Breath of Life is in a league of its own. My mouth feels cleaner, my breath stays fresher longer, and I love knowing I’m supporting my overall health every time I brush.

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