Nitric Oxide Oral Wellness Duo

Did you know that the secret to a healthy heart might actually live in your mouth?

For decades, we’ve treated oral care and heart health as separate disciplines. You see a dentist for your teeth and a cardiologist for your heart. However, groundbreaking science has revealed a critical “oral-systemic link.” Your mouth is not just a tool for eating and speaking; it is the gateway to your overall cardiovascular wellness.

At the center of this connection is a foundational molecule called nitric oxide.

As we age, our body’s ability to produce nitric oxide declines by over 50% by the age of 40, leading to reduced circulation, lower energy, and weaker heart health. While the body produces this molecule naturally, it relies heavily on a healthy oral microbiome to do so. Unfortunately, harsh antiseptic mouthwashes and fluoride toothpastes often destroy the beneficial bacteria needed for this process.

To address this, nitric oxide leader, Dr. Nathan S. Bryan, developed a revolutionary two-step system to restore this vital connection: Breath of Life Nitric Oxide Boosting Toothpaste and N1o1 Nitric Oxide Lozenges. Together, they cleanse, prime, and replenish your body to support optimal oral health and cardiovascular function.

The Science: How Your Mouth Powers Your Heart

The oral microbiome—the community of bacteria living in your mouth—is responsible for the first step in nitric oxide production. When this microbiome is disrupted by harsh chemicals or poor hygiene, your nitric oxide levels plummet.

Nitric oxide is the master signaling molecule in the cardiovascular system. It signals your blood vessels to relax and widen, allowing for:

Healthy blood pressure regulation
Improved oxygen delivery to organs
Enhanced athletic performance and recovery
Better cognitive function

By nurturing your oral microbiome rather than sterilizing it, you create the optimal environment for heart health to flourish.

Additional information

Weight	8 oz

How To Use

Step 1: Prime the Microbiome

Breath of Life Nitric Oxide Boosting Toothpaste

Most toothpastes are designed to sterilize. Breath of Life is designed to revitalize.

This is the world’s first nitric oxide-enhancing toothpaste. Unlike conventional products that strip your mouth of its natural defenses, Breath of Life is a fluoride-free formula crafted to support a healthy oral microbiome. It prepares the “soil” of your mouth, encouraging the growth of beneficial bacteria that convert dietary nitrates into nitric oxide.

Key Benefits May Support:

Oral Microbiome Support: Nurtures the beneficial bacteria essential for nitric oxide production.
Enhanced Gum Health: Improves micro-circulation in the gums to fight inflammation and bleeding.
Enamel Remineralization: Features Hydroxyapatite, a natural alternative to fluoride that rebuilds and strengthens tooth enamel.
Tartar Control: Zinc Citrate prevents plaque from hardening into tartar without harsh abrasion.
Natural Freshness: A blend of essential oils (Peppermint, Spearmint, Wintergreen) freshens breath while providing gentle antimicrobial benefits.

Step 2: Restore Systemic Levels

N1o1 Nitric Oxide Lozenges

Once you have primed your oral environment, the next step is to directly replenish your body’s nitric oxide levels.

N1o1 Nitric Oxide Lozenges are scientifically formulated to release nitric oxide gas as they dissolve in your mouth. This unique delivery system bypasses the digestive tract, allowing the molecule to be absorbed directly into the bloodstream through the oral mucosa. This mimics the body’s natural production mechanism, delivering immediate benefits to your circulation and energy levels.

Key Benefits May Support:

Circulatory Boost: Rapidly dilates blood vessels to improve flow throughout the entire body.
Heart Health Support: Helps maintain healthy blood pressure levels already within the normal range.
Cognitive Function: Increases blood flow to the brain, supporting focus and mental clarity.
Energy & Vitality: Enhances oxygen and nutrient delivery to muscles, reducing fatigue and boosting stamina.

The Combined Power of the N1o1 System

Using these products together creates a synergistic effect that addresses both the cause of nitric oxide decline (a disrupted microbiome) and the symptom (low systemic levels).

Your Daily Heart-Health Routine

Brush (Morning & Night): Use Breath of Life Toothpaste to clean teeth, remineralize enamel, and establish a nitrate-reducing microbiome.
Dissolve (Twice Daily): Place one N1o1 Nitric Oxide Lozenge in your mouth. Move it around slowly above your tongue as it dissolves (about 5-6 minutes). This floods your system with nitric oxide.

- Pro Tip: For best results, take one lozenge, twice daily 12 hours apart to maintain steady nitric oxide levels all day. Hydrate before use.
- If you’re finding sensitivity, alkalize your mouth with a baking soda and water mixture prior to taking the lozenge.

Ingredients

Clean, Clinical Ingredients

We believe in ingredients that work with your body, not against it.

Breath of Life Toothpaste

Highlights

Hydroxyapatite: For enamel strength.
Zinc Citrate: For plaque control.
Xylitol & Erythritol: To reduce harmful bacteria while sparing the good ones.
Botanical Blend: Peppermint, Tea Tree, Cinnamon, and Wintergreen oils.
No Fluoride, No Sulfates, No Harsh Antiseptics.

Nitric Oxide Lozenge

Highlights

Vitamin C (Magnesium Ascorbate): 164mg for antioxidant support.
Magnesium: Supports muscle function and reduces fatigue.
N1o1 Proprietary Blend: A specialized mix including Sodium Nitrite designed to generate nitric oxide gas upon dissolution.
Gluten-Free, Vegan, Non-GMO.

FAQs

Why shouldn't I just use regular mouthwash?

Most antiseptic mouthwashes kill 99.9% of bacteria indiscriminately — including the “good” bacteria your body relies on to produce nitric oxide. Shutting down that pathway can actually raise blood pressure. Breath of Life is formulated to clean without disrupting this delicate balance.

Are the toothpaste and lozenges safe for daily use?

Yes. Both Breath of Life Toothpaste and N1o1 Lozenges are formulated for daily use with safe, non-toxic, clinically backed ingredients. They are vegan, gluten-free, and free of harsh chemicals and artificial additives.

Can I use these products together?

Absolutely — they’re designed as a system. Using both together amplifies the benefits for oral microbiome support and nitric oxide production, supporting oral and systemic health.

When will I notice results?

Many people notice fresher breath and a cleaner mouth right away. Benefits like improved gum health, reduced sensitivity, and better energy or blood pressure support typically become noticeable within a few days to a few weeks of consistent use.

Do these replace my regular toothpaste and supplements?

Yes — you can use Breath of Life Toothpaste in place of your traditional toothpaste. The lozenges are unique and complement your routine, focusing specifically on nitric oxide and circulatory wellness.

Can children use these products?

Breath of Life Toothpaste is safe and suitable for the whole family, including children. The lozenges are formulated for adults — check with a healthcare provider for guidance regarding minors.

Can I use the toothpaste if I have sensitive teeth?

Yes. Breath of Life contains Potassium Nitrate, clinically used to soothe nerves and reduce sensitivity, plus Hydroxyapatite to strengthen the enamel barrier.

Are there any side effects?

Both products are generally well tolerated. Occasionally, those with very sensitive mouths may experience mild irritation from the lozenges, usually resolved by alkalizing the mouth beforehand (e.g., a baking-soda water rinse).

Take control of your health right where it starts.
By switching to a nitric oxide-focused oral care routine, you aren’t just getting a brighter smile—you are investing in better circulation, sustained energy, and a healthier heart.

Dr. Bryan

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.

Clinical Studies

[1] Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria
PubMed
Sandesh C S Nagamani, Philippe M Campeau, Oleg A Shchelochkov, Muralidhar H Premkumar, Kilian Guse, Nicola Brunetti-Pierri, Yuqing Chen, Qin Sun, Yaoping Tang, Donna Palmer, Anilkumar K Reddy, Li Li, Timothy C Slesnick, Daniel I Feig, Susan Caudle, David Harrison, Leonardo Salviati, Juan C Marini, Nathan S Bryan, Ayelet Erez, Brendan Lee
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Download the PDF

[2] The oral microbiome, nitric oxide and exercise performance
PubMed
Nathan S Bryan, Mia C Burleigh, Chris Easton
Nitric Oxide Innovations, LLC, Houston, TX, USA.
Institute for Clinical Exercise and Health Science, University of the West of Scotland, Blantyre, UK.
Download the PDF

[3] Functional Nitric Oxide Nutrition to Combat Cardiovascular Disease
PubMed
Nathan S Bryan
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Alkek Building for Biomedical Research R-850, Houston, TX, 77030, USA.
Read the Study

[4] Nitric oxide enhancement strategies
PubMed
Nathan S Bryan
Department of Molecular & Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Private Practice, Chernoff Cosmetic Surgeons, Ascension St. Vincent Hospital, Indianapolis IN, USA
Download the PDF

[5] Oral nitrite therapy improves vascular function in diabetic mice
PubMed
Amy L Sindler, Kimberly Cox-York, Lauren Reese, Nathan S Bryan, Douglas R Seals, Christopher L Gentile
Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA
Download the PDF

[6] Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure
PubMed
Nathan S Bryan, Gena Tribble, Nikola Angelov
Department of Molecular and Human Genetics, Baylor College of Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Periodontics, The University of Texas Health Science Center at Houston, 7000 Fannin, Houston, TX, 77030, USA.
Read The Study

[7] Nathan S. Bryan, PhD, points out how using antiseptic mouthwash can reduce good oral bacteria and cause high blood pressure and other conditions.
Dental Sleep Practice
Nathan S Bryan
Read the Study

[8] Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
PubMed
Nathan S Bryan, John W Calvert, John W Elrod, Susheel Gundewar, Sang Yong Ji, David J Lefer
Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.
Download the PDF

[9] Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults
PubMed
Allison E DeVan, Lawrence C Johnson, Forrest A Brooks, Trent D Evans, Jamie N Justice, Charmion Cruickshank-Quinn, Nichole Reisdorph, Nathan S Bryan, Matthew B McQueen, Jessica R Santos-Parker, Michel B Chonchol, Candace J Bassett, Amy L Sindler, Tony Giordano, Douglas R Seals

Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado
Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado
Integrated Department of Immunology, National Jewish Health, Denver, Colorado
Baylor College of Medicine, Houston, Texas
Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado
TheraVasc, Cleveland, Ohio

Download the PDF

[10] Oral nitrite therapy improves vascular function in diabetic mice
PubMed
Amy L Sindler, Kimberly Cox-York, Lauren Reese, Nathan S Bryan, Douglas R Seals, Christopher L Gentile

Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA

Download the PDF