N1o1 Nitric Oxide Body & Mind Essentials

Transform Your Health at a Cellular Level

As we age, our body’s natural ability to produce nitric oxide declines dramatically—a process that begins earlier than many realize. This isn’t just a small change; it affects your overall health, influencing key areas like blood circulation, energy levels, oral health, and even the tone and elasticity of your skin. Poor nitric oxide levels can lead to sluggishness, dull skin, and reduced vitality in daily life, making it harder to feel like the best version of yourself.

N1o1’s exclusive Body & Mind system is specially designed to address this decline by replenishing nitric oxide levels in your body. By restoring this essential molecule, it supports better blood flow for improved energy, contributes to healthier oral microbiome, and promotes a radiant, youthful appearance. Whether it’s feeling more energized throughout the day or noticing a refreshed glow in your skin, this solution helps you maintain vitality and confidence at every stage of life.

“Nitric oxide is considered one of the most important molecules produced in humans. This simple molecule controls oxygen and nutrient delivery to every cell in the body; it regulates cellular communication and even has anti-microbial properties that protect our body from invading pathogens. In fact, this molecule is so important it was named “Molecule of the Year” by Science Magazine in 1992 and in 1998 a Nobel Prize in Physiology or Medicine was awarded to the three US Scientists responsible for its discovery.”
— Dr. Nathan S Bryan

What's Included?

N1o1 Nitric Oxide Lozenges:

The Quick-Dissolve Boost

Experience an immediate surge of vitality with our revolutionary quick-dissolve lozenges. Perfect for on-the-go support, these lozenges are scientifically formulated to rapidly generate nitric oxide, supporting healthy circulation and blood pressure.

Instant Support: Feel the effects in minutes.
Cardiovascular Health: Promotes optimal heart function and blood flow.
Great Taste: A pleasant, easy way to boost your N.O. levels anytime, anywhere.

N.O. Beetz:

The Energizing Pre-Workout Drink
(Pre-converted for nitric oxide production)

Fuel your day and your workouts with the clean, natural power of N.O. Beetz. This delicious powdered drink mix transforms beets into a mess-free, oxalate-free, great-tasting powerhouse that enhances stamina and nutrient delivery.

Sustained Energy: Enjoy a natural energy lift without jitters or a crash.
Performance Enhancer: Improves oxygen delivery to cells for better endurance.
Supports Hydration: Improved cellular hydration with electrolytes.
Antioxidant Powerhouse: Supports your body's defense against oxidative stress.
For best use, do not take within 4 hours of the N1o1 Nitric Oxide Lozenge.

CardioSmile Nitric Oxide Toothpaste:

The Oral Health Revolution

Your oral health is the gateway to your overall well-being. CardioSmile is the first and only toothpaste designed to generate nitric oxide, supporting a healthy oral microbiome and promoting cardiovascular health.

Triple-Action Formula: Whitens teeth, remineralizes enamel, and freshens breath while supporting heart health.
Protects Oral Microbiome: Free from fluoride and other harsh ingredients that can disrupt good bacteria.
Systemic Benefits: A simple addition to your daily routine that contributes to whole-body wellness.

Age-Defiance Serum:

The Secret to Ageless Skin

Turn back the clock with our groundbreaking Nitric Oxide Activating Age-Defiance Serum. This is the hero skincare product that generates nitric oxide directly on your skin, visibly reducing fine lines, wrinkles, and dark spots. You can actually see your skin turn slightly pink as it’s working due to an increase of blood flow.

Cellular Rejuvenation: Stimulates collagen production and restores oxygen and nutrient flow to skin cells.
Proven Results: Backed by 5 clinical studies to improve skin tone, texture, and elasticity.
Radiant Glow: Revitalize dull, tired skin for a complexion that looks and feels more youthful and vibrant..

Essential for Your Health

Why Nitric Oxide is Essential for You:

As we age, our natural nitric oxide production declines, impacting energy, stamina, circulation, and even skin and oral health. N1o1 solutions are backed by Nobel Prize-winning science and over 25 years of research to:

Boost Circulation & Energy: Improve blood flow for better vitality and stamina.
Support Heart Health: Crucial for overall cardiovascular well-being.
Rejuvenate Skin: Enhance elasticity, reduce fine lines, and promote a youthful glow.
Strengthen Oral Health: Support a healthy oral microbiome and gums.
Combat Oxidative Stress: Protect your body from environmental damage.

Why the N1o1 Nitric Oxide Body & Mind Essentials is a Must-Have:

Synergistic Formulas: Designed to work together for maximum nitric oxide activation, both internally and externally.
Targeted Anti-Aging & Wellness: Optimize nitric oxide levels for improved memory, focus, heart health, physical performance, and age-defying results.
Backed by Biochemistry: Created by Dr. Nathan S. Bryan, a world-renowned nitric oxide researcher.
Biohacker Approved: Promotes healthy blood pressure, circulation, and visibly improves oral and skin health.
Science Meets Simplicity: Clean, effective, non-toxic formulas that seamlessly fit into your daily routine.
Long-Term Results: A proven routine for sustained, visible skin improvement and enhanced overall health.

How to Use

N1o1 Nitric Oxide Lozenges:

Take One N1o1 Nitric Oxide Lozenge, Twice a Day to Undo Years of Damage

Hydrate before use. Place one lozenge in the mouth, moving the tablet around over the top of the tongue as it dissolves. Once the tablet has fully dissolved, swallow the remaining saliva.

NOTE: If you have acidic saliva, alkalize your mouth by swishing with a mixture of baking soda and water before use.

*This is a dietary supplement not intended to diagnose, treat, cure, or prevent any diseases.

Ingredients

Science Backed Ingredients

N1o1 Nitric Oxide Lozenges

Key Ingredients:

Vitamin C & Magnesium (essential nutrients), NO2U™ Proprietary Blend (Magnesium Ascorbate, Sodium Nitrite for nitric oxide activation).

Full ingredient list:

Vitamin C (from Magnesium Ascorbate), Magnesium (from Magnesium Ascorbate), NO2U™ Proprietary Blend [Magnesium Ascorbate, Sodium Nitrite], Mannitol, Microcrystalline Cellulose, Dextrin, Natural Flavors, Croscarmellose Sodium, Maltodextrin, Stearic Acid, Vegetable Stearate, Food Starch – Modified, Starch, Silica, Stevia, Citric Acid, Monk Fruit

N.O. Beetz

Key Ingredients:

Vitamins C & D (antioxidant, immune support), Electrolytes (Magnesium, Zinc, Manganese, Sodium, Potassium), NO2U™ Proprietary Blend, Fermented Beet Root Powder (preconverted for nitric oxide production), D-Ribose & PEAK ATP® (cellular energy).

Full ingredient list:

Vitamin C (as Ascorbic Acid), Vitamin D (as Cholecalciferol), Magnesium (as DiMagnesium Malate), Zinc (as Zinc Bisglycinate Chelate), Manganese (as Manganese Bisglycinate Chelate), Sodium, Potassium, NO2U™ Proprietary Blend, Fermented Beet Root Powder, D-Ribose, PEAK ATP® (Adenosine 5′-Triphosphate Disodium), Citric Acid, Sea Salt, Rebaudioside A (Stevia Extract), Malic Acid, Natural Flavor

CardioSmile Nitric Oxide Toothpaste

Key Ingredients:

Potassium Nitrate (sensitivity relief), Xylitol (cavity prevention), Hydroxyapatite (enamel remineralization), Zinc Citrate (plaque/gingivitis control), Essential Oils (Peppermint, Spearmint, Wintergreen, Tea Tree, Eucalyptus, Thyme for fresh breath & antiseptics).

Full ingredient list:

Glycerin, Water, Sorbitol, Hydrated Silica, Calcium Carbonate, Potassium Nitrate, Xylitol, Hydroxyapatite 4 Mentha Piperita (Peppermint) Oil, Xanthan Gum, Mentha Spicata (Spearmint) Leaf Oil, Gaultheria Procumbens (Wintergreen) Leaf Oil, Menthol, Cocos Nucifera (Coconut) Oil, Zinc Citrate, Citrus Aurantium Dulcis (Orange) Peel Oil, Citrus Limon (Lemon) Peel Oil, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Cinnamomum Zeylanicum Bark Oil, Eucalyptus Globulus Leaf Oil, Thymus Vulgaris (Thyme) Flower/Leaf Oil, Erythritol, Cellulose Gum, Sodium Lauroyl Sarcosinate

Nitric Oxide Activating Anti-Aging Serum

Key Ingredients:

Ascorbic Acid (Vitamin C, antioxidant, collagen support), Sodium Nitrite (activates nitric oxide for skin repair), d-Tocopheryl Acetate (Vitamin E, antioxidant protection).

Full ingredient list:

Water, Ascorbic Acid (Vit. C), Polysorbate 20, Hydroxyethylcellulose, Sodium Nitrite, d-Tocopheryl Acetate (Vit. E), Dehydroacetic Acid, Benzyl Alcohol, Sodium Sulfite, Sodium Metabisulfite, Tetrasodium EDTA.

FAQs

What’s happening in my body as I take the N1o1 Nitric Oxide Lozenge?

Timeline of Physiological Effects Induced by a N1o1 Nitric Oxide Lozenge

Discover what’s happening in your body when you use a N1o1 Nitric Oxide Lozenge, from its physiological effects to how it quietly supports your overall health—even if you can’t feel it.

12 Seconds – Carotid arteries begin to dilate, increasing blood flow to the brain.
1 Minute – Blood vessels dilate, enhancing circulation throughout the body.
5 Minutes – Notice a 2.1% boost in exercise performance.
10 Minutes – Carotid arteries dilate by 13%, leading to a 34% increase in blood flow to the brain and body.
20 Minutes – For individuals with elevated blood pressure (130-139/80-89 mmHg), systolic and diastolic blood pressure drops by 5-6 mmHg.
20-30 Minutes – Blood vessels become more flexible and compliant, improving vascular function by 20% and reducing arterial strain.
60 Minutes – Elevated blood pressure drops further by 8-10 mmHg, with some cases seeing reductions of up to 50-60 mmHg for extremely high readings.
4 Hours – Endothelial function improves by 15-25%, boosting natural nitric oxide production.
2 Weeks – Blood flow regulation improves, enhancing mitochondrial function and exercise capacity.
3 Weeks – Reduced oxidative stress and inflammation.
1 Month – Blood pressure in pre-hypertension and hypertension patients decreases by 12 mmHg systolic and 6 mmHg diastolic, triglycerides drop by 27%, and cardiovascular health improves.
6 Months – Existing arterial plaque stabilizes and begins to regress by 11%; endothelial function normalizes.
9 Months – Kidney function improves, protein excretion decreases, and cardiac function strengthens, including reduced cardiac hypertrophy.
12 Months – Arterial health improves, telomeres stabilize, and antioxidant defenses combat post-meal oxidative stress and inflammation. Cognitive gains include better verbal memory and problem-solving skills.

Experience the comprehensive benefits of N1o1 Nitric Oxide Lozenges and transform your cardiovascular health at every stage.

What’s happening in my body as I take N.O. Beetz?

Timeline of Benefits with N.O. Beetz

Discover how N.O. Beetz works to support your health step by step:

Within Minutes: Blood vessels begin to dilate, improving circulation and oxygen delivery.
Within Hours: Enhanced nitric oxide levels lead to better energy, stamina, and focus.
Within Weeks: Consistent use supports cardiovascular health, reduced oxidative stress, and improved endurance.
Within Months: Long-term benefits include stabilized blood pressure, reduced arterial plaque, more mitochondria per cell producing more energy more efficiently and improved overall vitality

Experience the Power of N.O. Beetz
Transform your health and performance with N.O. Beetz, the natural, science-backed solution for boosting nitric oxide levels.

What makes CardioSmile Nitric Oxide Toothpaste different from other toothpastes on the market?

CardioSmile is a first-of-its-kind toothpaste, designed to actively support your body’s nitric oxide ecosystem, beyond just cleaning teeth.

What makes it different:

Nitric oxide focus: The world’s first toothpaste supporting nitric oxide production and a healthy oral microbiome, linking oral care to whole-body circulation and cardiovascular wellness.
Fluoride free remineralization: Uses hydroxyapatite to strengthen and rebuild enamel, gentle on teeth and gums.
Oral microbiome support: Nurtures beneficial bacteria, avoids harsh antiseptics that suppress nitric oxide pathways, and maintains healthy saliva pH.
Sensitivity & tartar control: Potassium nitrate reduces sensitivity; zinc citrate, hydrated silica, and calcium carbonate control tartar and polish without aggressive abrasives.
Clean essential oils: Peppermint, spearmint, wintergreen, tea tree, and cinnamon provide natural antimicrobial breath freshening, free from chemical aftertaste.
Doctor-developed credibility: Created by leading nitric oxide researcher, Dr. Nathan S. Bryan, aligning with N1o1’s science-backed approach.

CardioSmile redefines toothpaste as a daily nitric oxide routine, supporting gum circulation, enamel health, fresh breath, and a resilient oral microbiome—all while being fluoride and harsh antiseptic-free.

What makes N1o1 Nitric Oxide Activating Age-Defiance Serum unique?

N1o1 Nitric Oxide Activating Age-Defying Skincare Serum stands out for several key reasons:

First and only nitric oxide–generating serum: Unlike conventional serums, it actively generates nitric oxide on the skin’s surface. This addresses aging at a cellular level by improving oxygen and nutrient delivery to skin cells, boosting collagen, hydration, and healthy metabolism.
Dual‑chamber activation you can see: The two-part system mixes on application, visibly activating in seconds. A brief pink flush indicates increased nitric oxide activity, a visible sign of activation.
Clinically backed outcomes: Multiple clinical studies support improvements in wrinkles, pore size, skin tone, texture, clarity, and dark spots with regular use.
Synergy with Vitamin C and antioxidants: It combines nitric oxide activation with 20% Vitamin C and Vitamin E, enhancing brightening, collagen support, and free‑radical defense for comprehensive results.
Simple, high‑impact routine: Each bottle provides up to ~70 applications. Apply one pump from each chamber, twice daily on clean skin, and allow 1–2 minutes to absorb. This makes clinical‑grade results achievable with minimal effort.
Science led by a nitric oxide pioneer: Developed by Dr. Nathan S. Bryan, a leading authority in nitric oxide biochemistry, bringing two decades of research to daily skincare.

Bottom line: This serum doesn’t just layer antioxidants; it restores nitric oxide at the skin surface to re‑energize cellular function, helping skin look and act younger.

When can I expect to see or feel results?

Many users feel an immediate sense of refreshment from the toothpaste and an energy lift from the lozenges and N.O. Beetz (it’s best to space these 4 hours apart). With consistent daily use of the Age-Defiance Serum, visible improvements in skin tone, texture, and the appearance of fine lines are often reported within 30 days.

What does a daily routine with this kit look like?

Morning: Start by brushing with CardioSmile Toothpaste. Then, apply the Age-Defiance Serum to clean skin. Use N.O. Beetz for sustained energy or a pre-workout boost.

Throughout the Day: Use a N1o1 Nitric Oxide Lozenge as needed for a quick vitality lift.

Evening: Brush with CardioSmile Toothpaste and apply the Age-Defiance Serum before bed.

Dr. Bryan

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.

Research & Studies

[1] The Utilization of a Topical Nitric Oxide Generating Serum in the Aging Skin Population: A Pilot Study
Annals of Plastic & Reconstructive Surgery
Greg Chernoff* MD, FRCS(C)
Chernoff Plastic Surgery, Indianapolis, Indiana, Santa Rosa, California, US
Download the PDF

[2] The Utilization of a Nitric Oxide Generating Serum in the Treatment of Active Acne and Acne Scarred Patients
International Journal of Pharmaceutica Analytica Acta
Greg Chernoff
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF

[3] The Utilization of a Nitric Oxide Generating Serum for Improving Vascularity in Wound Healing
Science Repository
Greg Chernoff
Ascension St. Vincent Hospital, USA
Download the PDF

[4] The Utilization of a Topical Nitric Oxide Generating Serum in Aesthetic Medicine
Gavin Publishers
Gregory Chernoff BSc, MD, FRCS(C)
Private Practice, Chernoff Cosmetic Surgeons, Ascension St. Vincent Hospital, Indianapolis IN, USA
Download the PDF

[5] A Novel Combination Therapy in Aesthetic and Reconstructive Surgery: Sea Salt Exfoliation, Cavitating Ultrasound, and High Intensity Multiwavelength LED Treatment: (SaltFacial)
Sciforschen Journal of Clinical and Cosmetic Dermatology
Greg Chernoff, BSc, MD, FRCSC*
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF

[6] Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria
PubMed
Sandesh C S Nagamani, Philippe M Campeau, Oleg A Shchelochkov, Muralidhar H Premkumar, Kilian Guse, Nicola Brunetti-Pierri, Yuqing Chen, Qin Sun, Yaoping Tang, Donna Palmer, Anilkumar K Reddy, Li Li, Timothy C Slesnick, Daniel I Feig, Susan Caudle, David Harrison, Leonardo Salviati, Juan C Marini, Nathan S Bryan, Ayelet Erez, Brendan Lee
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Download the PDF

[7] The oral microbiome, nitric oxide and exercise performance
PubMed
Nathan S Bryan, Mia C Burleigh, Chris Easton
Nitric Oxide Innovations, LLC, Houston, TX, USA.
Institute for Clinical Exercise and Health Science, University of the West of Scotland, Blantyre, UK.
Download the PDF

[8] Functional Nitric Oxide Nutrition to Combat Cardiovascular Disease
PubMed
Nathan S Bryan
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Alkek Building for Biomedical Research R-850, Houston, TX, 77030, USA.
Download the PDF

[9] Nitric oxide enhancement strategies
PubMed
Nathan S Bryan
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Alkek Building for Biomedical Research R-850, Houston, TX, 77030, USA.
Download the PDF

[10] Oral nitrite therapy improves vascular function in diabetic mice
PubMed
Amy L Sindler, Kimberly Cox-York, Lauren Reese, Nathan S Bryan, Douglas R Seals, Christopher L Gentile

Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA

Download the PDF

36 reviews for N1o1 Nitric Oxide Body & Mind Essentials

Rated 5 out of 5

Courtney P – 07/23/2025

I recently started using the CardioSmile Nitric Oxide Toothpaste and WOW, it tastes amazing! I have been using another brand of toothpaste without flouride for the past 7 years, but was so excited to change to this one that has the extra benefits of increasing my nitric oxide production. Give it a try, you will love it!
Rated 5 out of 5

B. McLaughlin – 07/25/2025

The clean ingredients and fluoride-free formula while boosting your nitric oxide production makes this a standout product.
Rated 5 out of 5

Amanda J. – 07/25/2025

This is the ultimate upgrade to oral care. I love how it optimizes oral health while staying free of harmful chemicals.
Rated 5 out of 5

Michael S. – 07/25/2025

Not only does CardioSmile keep my mouth feeling fresh all day, but the focus on nitric oxide benefits is a total game-changer for my health!
Rated 5 out of 5

Daniel H. – 07/25/2025

Convenient, effective, refreshing AND good for my health! Couldn’t ask for more! Dr. Bryan is a genius—changing the dental industry!
Rated 5 out of 5

Sophie C. – 07/25/2025

Finally, a product that combines science and clean living! My mouth feels fantastic, and I love knowing it’s made with good ingredients.
Rated 5 out of 5

J. Ahn – 07/25/2025

Instant clean! Fresh and invigorating.
Rated 5 out of 5

Christian P. – 07/25/2025

CardioSmile tastes great and I highly recommend it! I’ve tried several other fluoride-free toothpaste brands and they don’t even come close. Dr. Bryan, hats off to you for this creation.
Rated 5 out of 5

Catherine L. – 07/25/2025

I love how this supports both my cardiovascular and oral health! What a revolutionary step in science!
Rated 5 out of 5

KF (verified owner) – 08/01/2025

I’ve been using the toothpaste for about a month. My teeth are very sensitive and I find less issues while using N1O1 toothpaste then sensodyne. My mouth feels fresher and I will be using this from now on. On top of the quality TP I get a nitric oxide boost .
Rated 5 out of 5

David Johnson (verified owner) – 08/18/2025

Honestly the best toothpaste I’ve tried in years. It tastes super fresh and I love knowing it’s actually helping my health too
Rated 5 out of 5

Jeff Howarth (verified owner) – 08/18/2025

I was skeptical at first, but this toothpaste feels so clean and natural. My mouth feels fresh all day without the chemical aftertaste.
Rated 4 out of 5

Alan Grodon (verified owner) – 08/18/2025

Finally found a toothpaste that’s good for me and doesn’t feel harsh. Love that it helps with nitric oxide too.
Rated 5 out of 5

Melissa Pressler (verified owner) – 08/18/2025

I’ve switched my whole family over to this. The flavor is great, and it just feels healthier than what we were using before
Rated 4 out of 5

Larry Barron (verified owner) – 08/18/2025

Never thought I’d notice a difference with toothpaste, but this one really does make me feel better overall. Definitely sticking with it.
Rated 3 out of 5

CJ – 08/19/2025

I do like all the benefits this toothpaste provides, but why so expensive? I use a product without fluoride that is half the cost and as someone on a fixed income, this double price is just too mush for me. A sample came with my last order, but won’t be buying until the price is more in keeping with my budget.
Rated 5 out of 5

Allan – 08/25/2025

I’ll admit, I was skeptical about switching from my regular toothpaste, but CardioSmile has completely transformed my oral care routine! As someone who drinks coffee daily and has always struggled with plaque buildup despite regular brushing, I was looking for something that could make a real difference.

After just two weeks of using CardioSmile, my dental hygienist commented on how much cleaner my teeth looked—and this was during my regular cleaning appointment! The plaque that used to accumulate so quickly has been dramatically reduced, and my teeth feel smooth and clean all day long.

What I love most is how fresh my breath stays throughout the day. I used to reach for mints after lunch, but now my mouth still feels clean and fresh hours after brushing. The fluoride-free formula was a huge selling point for me since I’ve been trying to reduce chemical exposure, and knowing that it’s actually supporting my oral microbiome while boosting nitric oxide production makes me feel great about my choice.
Rated 5 out of 5

Lilian chung – 08/25/2025

The taste is absolutely perfect—refreshing without being overwhelming, and it leaves my mouth feeling genuinely clean, not just masked with artificial flavors. This toothpaste has exceeded every expectation I had. Dr. Bryan has created something truly revolutionary for oral health!
Rated 5 out of 5

Graclyn Parie – 08/25/2025

I’ve struggled with sensitive teeth and gum irritation, trying everything from prescription toothpastes to expensive dental treatments. When my dentist mentioned that my gums were showing more signs of inflammation, I knew I needed to find a better solution. After a month of using cardiosmile, my tooth sensitivity decreased noticeably. My gums feel so much healthier and less tender, and I love that the clean, natural ingredients are actually supporting my mouth’s microbiome instead of disrupting it like harsh chemicals do
Rated 5 out of 5

Jeff Abouaf (verified owner) – 09/08/2025

I’ve been fluoride-free for years because I care about what goes in my body, but switching to CardioSmile Toothpaste has been a total win. It tastes incredible and the added nitric oxide support makes it feel like I’m doing something good for my health every time I brush. Highly recommend.
Rated 5 out of 5

Mike Zapata (verified owner) – 09/08/2025

Brushing my teeth is usually just another task to check off, but this toothpaste actually makes it enjoyable. The flavor is incredibly fresh, and I love knowing it’s providing me with extra health benefits beyond just cleaning my teeth. Finally, a toothpaste I actually look forward to using!
Rated 5 out of 5

Fitness Junkie (verified owner) – 09/08/2025

I’m all about performance and recovery, so finding a toothpaste that helps boost nitric oxide was a surprise. CardioSmile doesn’t just taste great, it ties right into my lifestyle. A simple swap that supports my workouts and my overall health — I’m hooked.
Rated 5 out of 5

Amanda Klass (verified owner) – 09/08/2025

Honestly, I thought all toothpaste was basically the same. But after trying CardioSmile, I get why people rave about it. The taste is awesome, my mouth feels cleaner than ever, and the idea of boosting nitric oxide while brushing? Pretty amazing.
Rated 5 out of 5

Vincent – 09/10/2025

I switched to CardioSmile right shortly after a dental checkup. I have used it consistently since then. I had a dental checkup last week. The dentist was very pleased with what he found. My teeth and my gums are in fantastic shape. Best dental checkup I’ve had in a long time. It tastes good tood.
Rated 5 out of 5

Matthew – 09/15/2025

After using this product since launch my gums feel healthier and my stays fresh. I specifically love that it’s fluoride free. It’s nice knowing my toothpaste is doing more than just cleaning my teeth. Highly recommend!
Rated 5 out of 5

Derrick R – 09/17/2025

Hands down the best toothpaste I’ve ever used. My smile looks better than it has in years and my mouth just feels cleaner & healthier. I will be recommending this to my dentist the next time I see him!
Rated 4 out of 5

Sam B. (verified owner) – 09/22/2025

Love that it has heart health boosting benefits in addition to oral health. Wish is was mintier
Rated 4 out of 5

lydia p. (verified owner) – 09/22/2025

Great formula and I’m a huge fan of Dr. Bryan’s work on nitric oxide. The toothpaste tub is kinda hard to squeeze out especially when you get to the bottom.
Rated 5 out of 5

Kim (verified owner) – 09/30/2025

At 70 years old they R making a difference thank U
Rated 5 out of 5

Kim (verified owner) – 09/30/2025

It’s really making a difference thank U regards kim
Rated 5 out of 5

Carolyn Page (verified owner) – 10/10/2025

Could not be happier. Dr Bryan, you deserve every accolade you receive. This is a total game changer. Fresh breath, clean mouth, and overall health support is becoming obvious with every brush. Thank you so much.
Rated 5 out of 5

Jeff R. (verified owner) – 10/14/2025

I am very thankful for Dr. Nathan Bryan’s 30 years of research on Nitric Oxide. I use the toothpaste and also use the nitric oxide tablets and am seeing results from both. I had no idea how important N.O. is until I found out from Dr. Bryan’s podcasts. Low levels of N.O. can affect blood pressure and A1C and me being a mouth breather isnt good either since mouth breathing doesnt naturally produce nitric oxide. Thanks for the creation of these products and I will keep using them.
Jeff R.
Rated 5 out of 5

Shane Bruno (verified owner) – 10/23/2025

Science-backed and effective — this is the future of toothpaste!
Rated 5 out of 5

matt nichol (verified owner) – 10/23/2025

Fresh breath + stronger teeth + nitric oxide boost 🔥
Rated 5 out of 5

jarret finley (verified owner) – 10/23/2025

The detail and research behind this is amazing! Love how Dr. Bryan always brings science and health together
Rated 5 out of 5

zoe cruise (verified owner) – 10/23/2025

Cardiosmile is literally changing the game for oral health!!!