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Healthier Gums. Brighter Smiles. More Confidence.

Your oral health thrives on strong circulation, healthy gums, a balanced microbiome, and optimal performance. But as you age, nitric oxide production declines — leading to weaker gum health, reduced blood flow, and a less vibrant smile. Conventional fluoride toothpastes and antiseptic mouthwashes make it worse by disrupting the very oral bacteria that produce nitric oxide.

That’s why we created Breath of Life Nitric Oxide Boosting Toothpaste — a revolutionary formula designed to support the oral microbiome that boosts nitric oxide levels, improves circulation, and supports gum health, so you can enjoy a healthier smile every day.

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“We have known for more than 100 years that poor oral hygiene leads to increased risk of cardiovascular disease. Today we know that the oral microbiome responsible for optimizing nitric oxide production accounts for the oral-systemic link. Stringent antiseptics, fluoride, and poor oral hygiene all disrupt the oral microbiome. Our nitric oxide–focused line of oral care supports the microbiome, improving nitric oxide production — and thereby oral and systemic health.”

—Dr. Nathan S. Bryan, international expert in nitric oxide biochemistry

How Nitric Oxide Impacts Your Oral Health

This fluoride-free toothpaste is crafted to support a healthy oral microbiome while boosting nitric oxide production  enhancing gum circulation and promoting cardiovascular wellness. Its natural remineralizing properties strengthen enamel, control tartar, and reduce sensitivity. The only toothpaste targeting the nitric oxide microbiome.
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Freshens Breath Naturally

Inhibits the growth of cavity-causing bacteria while leaving your mouth fresh and clean.

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Boosts Blood Flow & Circulation

Helps boost circulation for healthier gums and improved cardiovascular function.

N1O1 nitric oxide oral health and nitric oxide microbiome and nitric oxide production

Oral Microbiome Support

Nurtures beneficial bacteria for a balanced, resilient oral microbiome.

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Supports Gum Health

Promotes blood flow and helps fight harmful bacteria to support healthy gums.

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Reduces Plaque Build-Up

Supports healthy saliva pH to neutralize acids and reduce plaque buildup.

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Elevates Mood & Energy

Feel more vibrant and energized with the natural boost nitric oxide provides.

The Oral-Systemic Link, Backed by Science

The first step of nitric oxide production happens in your mouth. Beneficial oral bacteria convert dietary nitrates into nitrite, which your body turns into nitric oxide — the master molecule that relaxes and widens blood vessels. When harsh antiseptics or fluoride wipe out those bacteria, the pathway shuts down, blood pressure can rise, and gum and heart health both suffer.

Breath of Life is engineered to protect that pathway, not destroy it. It cleans and remineralizes like a premium fluoride-free, hydroxyapatite toothpaste — the same approach embraced by the best-selling natural brands — then goes further by actively supporting the microbiome that fuels nitric oxide production.

Watch and learn as Susan Shaffer shares how Breath of Life supports the oral microbiome, promotes nitric oxide production, and helps elevate oral and whole-body wellness with a fluoride-free formula.

Susan Shaffer
President & Co-Founder of N1o1 Nitric Oxide

What is nitric oxide?
Nitric oxide (NO) is a molecule that helps relax and widen blood vessels — improving circulation, oxygen delivery, and cardiovascular health. It also supports energy, endurance, cognitive function, oral health, and sexual function.
It improves blood flow to the gums and supports your body’s natural defenses against harmful bacteria. It also aids saliva production, which keeps the mouth clean and neutralizes enamel-eroding acids. Without enough nitric oxide, these functions can become compromised, leading to oral-health problems.
It’s the world’s first toothpaste built around nitric oxide production and a healthy oral microbiome — remineralizing with hydroxyapatite instead of fluoride, nurturing beneficial bacteria rather than wiping them out, relieving sensitivity with potassium nitrate, and freshening with clean essential oils. Developed by leading nitric oxide researcher Dr. Nathan S. Bryan.
Many people report an immediately clean, fresh-feeling mouth. Within a couple of days, the oral microbiome and salivary pH improve, and many report more energy and better circulation. Consistent use over a few weeks delivers the best long-term benefits.
Yes. It’s formulated for daily use with clean, non-toxic ingredients, and potassium nitrate plus hydroxyapatite make it comfortable for sensitive teeth. Suitable for the whole family.
Dr. Nathan Bryan Dr. Nathan Bryan nitric oxide researcher

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. With more than 25 years of research in cardiovascular health, his discoveries have shaped the field of nitric oxide therapy and led to product innovations that have improved patient care worldwide.

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A Pioneer in Nitric Oxide Science

With over 25 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.

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Clinically Backed & Scientifically Proven

His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the N1o1 CardioSmile Nitric Oxide Boosting Toothpaste you’re about to experience.

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On a Mission to Improve Lives

Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.

Natural, Powerful Ingredients

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. With more than 25 years of research in cardiovascular health, his discoveries have shaped the field of nitric oxide therapy and led to product innovations that have improved patient care worldwide.

Hydroxyapatite

Rebuilds and strengthens enamel — a natural, fluoride-free alternative for long-lasting protection.

Potassium Nitrate

Soothes nerve endings to reduce tooth sensitivity.

Zinc Citrate

Helps prevent plaque from hardening into tartar.

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Xylitol & Erythritol

A natural ingredient known for its anti-inflammatory and healing properties, often used to reduce swelling, bruising, and pain

Hydrated Silica & Calcium Carbonate

Gently polish teeth to remove surface stains for a brighter smile — without harsh abrasion.

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Essential Oil Blend

Peppermint, spearmint, wintergreen, tea tree, and cinnamon for fresh breath and natural antimicrobial benefit.

Full Ingredient List

Glycerin, Water, Sorbitol, Hydrated Silica, Calcium Carbonate, Potassium Nitrate, Xylitol, Hydroxyapatite, Mentha Piperita (Peppermint) Oil, Xanthan Gum, Mentha Spicata (Spearmint) Leaf Oil, Gaultheria Procumbens (Wintergreen) Leaf Oil, Menthol, Cocos Nucifera (Coconut) Oil, Zinc Citrate, Citrus Aurantium Dulcis (Orange) Peel Oil, Citrus Limon (Lemon) Peel Oil, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Cinnamomum Zeylanicum Bark Oil, Eucalyptus Globulus Leaf Oil, Thymus Vulgaris (Thyme) Flower/Leaf Oil, Erythritol, Cellulose Gum, Sodium Lauroyl Sarcosinate.